{"id":22,"date":"2015-06-15T11:01:33","date_gmt":"2015-06-15T09:01:33","guid":{"rendered":"http:\/\/members.loria.fr\/thierrygartiser\/?page_id=22"},"modified":"2021-03-30T16:40:19","modified_gmt":"2021-03-30T14:40:19","slug":"projets","status":"publish","type":"page","link":"https:\/\/members.loria.fr\/LBuhry\/projets\/","title":{"rendered":"Projects"},"content":{"rendered":"

Page under construction<\/p>\n

Keywords<\/strong> : computational neuroscience, biophysically realistic mathematical modeling, spiking neurons, Hodgkin-Huxley formalism,memory, epilepsy, general anesthesia, Parkinson disease, hippocampus, basal ganglia<\/p>\n

Modeling and Simulation of the Healthy and Epileptic Hippocampus<\/h4>\n

The hippocampus is involved in several memory processes and exhibits oscillations in a wide range of frequencies correlated with specific functions. These patterns differ in sleep and wakefulness. For instance, theta (5-10Hz) and gamma (30-100Hz) rhythms are typically coupled in spatial navigation and working memory tasks during active wakefulness, whereas delta oscillations (1-4Hz) and Sharp-Wave-Ripple (SWR) complexes (130-200Hz) play an important role in memory consolidation and appear during slow-wave
\nsleep and quiet wakefulness. In addition, these rhythms are disturbed in pathological conditions such as epilepsy.<\/p>\n

In collaboration with:<\/em>
\nMotoharu Yoshida, Deutsches Zentrum f\u00fcr Degenerative Erkrankungen, Helmoltz-Gemeinschaft, Magdeburg, Germany : animal neurophysiology
\nRadu Ranta, Val\u00e9rie Louis-Dorr, Steven le Cam, Laurent Koessler, Centre de Recherche en Automatique de Nancy (CRAN), Nancy, France: signal processing
\nLouis Maillard, Louise Tyvaert, Olivier Aaron, Nicolas Carpentier, University Hospital (CHRU)-CRAN, Nancy : neurology, human neurophysiology, epilepsy, sleep<\/p>\n

 <\/p>\n

Modeling the Effects of General Anesthesia on Neuronal Activity<\/h4>\n

Application to the understanding of possible mechanisms underlying memory processes under general anesthesia<\/p>\n

 <\/p>\n

Modeling and Simulation of Basal Ganglia<\/h4>\n

Applications to the understanding of Parkinson’s disease rhythmogenesis<\/p>\n

In collaboration with:<\/em>
\nJ\u00e9r\u00f4me Beaufreton, Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, Bordeaux, France: animal neurophysiology
\nDominique Martinez, LORIA
\nSylvain Contassot-Vivier, LORIA: High-Performance Computing<\/p>\n

 <\/p>\n

Modeling of Electrical Retinal Activity: Applications in Neuropsychiatry<\/h4>\n

Changes in amplitude and latency of ElectroRetinoGram (ERG) signals are observed under psychiatric conditions and\/or in presence of drug consumption.
\nFrom a developmental point of view, the retina is an extension of the brain. As such, retinal cells exhibit an electrical activity that can be modeled with the Hodgkin-Hyxley formalism. This project aims at studying the role of ionic channels and ionic homeostasis in pathophysiological neuronal activity<\/p>\n

In collaboration with:<\/em>
\nVal\u00e9rie Louis-Dorr, Centre de Recherche en Automatique de Nancy (CRAN), Nancy, France: signal processing
\nand clinicians from the University Hospital of Nancy<\/p>\n

 <\/p>\n

Synchronization Mechanisms in Neuronal Network Models<\/h4>\n

In collaboration with:
\n<\/em> LieJune Shiau, Department of Mathematics, University of Houston Clearlake, Houston, Texas.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Page under construction<\/p>\n

Keywords : computational neuroscience, biophysically realistic mathematical modeling, spiking neurons, Hodgkin-Huxley formalism,memory, epilepsy, general anesthesia, Parkinson disease, hippocampus, basal ganglia<\/p>\n

Modeling and Simulation of the Healthy and Epileptic Hippocampus<\/p>\n

The hippocampus is involved in several memory processes and exhibits oscillations in a wide range of frequencies correlated with specific functions. These patterns differ in sleep and wakefulness. For instance, theta (5-10Hz) and gamma (30-100Hz) rhythms are typically coupled in spatial navigation and working memory tasks during active wakefulness, whereas delta oscillations (1-4Hz) and Sharp-Wave-Ripple (SWR) complexes (130-200Hz) play an important role in memory consolidation and appear during slow-wave
\nsleep and quiet wakefulness.<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-fullwidth.php","meta":{"footnotes":""},"class_list":["post-22","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/members.loria.fr\/LBuhry\/wp-json\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/members.loria.fr\/LBuhry\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/members.loria.fr\/LBuhry\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/members.loria.fr\/LBuhry\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/members.loria.fr\/LBuhry\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":11,"href":"https:\/\/members.loria.fr\/LBuhry\/wp-json\/wp\/v2\/pages\/22\/revisions"}],"predecessor-version":[{"id":363,"href":"https:\/\/members.loria.fr\/LBuhry\/wp-json\/wp\/v2\/pages\/22\/revisions\/363"}],"wp:attachment":[{"href":"https:\/\/members.loria.fr\/LBuhry\/wp-json\/wp\/v2\/media?parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}