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Publications HAL de Hamed Khakzad

2024

Journal articles

titre
The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies
auteur
Arman Izadi, Yasaman Karami, Eleni Bratanis, Sebastian Wrighton, Hamed Khakzad, Maria Nyblom, Berit Olofsson, Lotta Happonen, Di Tang, Martin Sundwall, Magdalena Godzwon, Yashuan Chao, Alejandro Gomez Toledo, Tobias Schmidt, Mats Ohlin, Michael Nilges, Johan Malmström, Wael Bahnan, Oonagh Shannon, Lars Malmström, Pontus Nordenfelt
article
Nature Communications, 2024, 15 (1), pp.3600. ⟨10.1038/s41467-024-47928-8⟩
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Journal articles
DOI
DOI : 10.1038/s41467-024-47928-8
Accès au texte intégral et bibtex
https://hal.science/hal-04567019/file/s41467-024-47928-8.pdf BibTex

2023

Journal articles

titre
A new age in protein design empowered by deep learning
auteur
Hamed Khakzad, Ilia Igashov, Arne Schneuing, Casper Goverde, Michael Bronstein, Bruno Correia
article
Cell Systems, 2023, 14 (11), pp.925-939. ⟨10.1016/j.cels.2023.10.006⟩
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Journal articles
DOI
DOI : 10.1016/j.cels.2023.10.006
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titre
Shigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint
auteur
Cesar Valencia-Gallardo, Daniel-Isui Aguilar-Salvador, Hamed Khakzad, Benjamin Cocom-Chan, Charles Bou-Nader, Christophe Velours, Yosra Zarrouk, Christophe Le Clainche, Christian Malosse, Diogo Borges Lima, Nicole Quenech’du, Bilal Mazhar, Sami Essid, Marc Fontecave, Atef Asnacios, Julia Chamot-Rooke, Lars Malmström, Guy Tran van Nhieu
article
Cell Reports, 2023, 42 (4), pp.112405. ⟨10.1016/j.celrep.2023.112405⟩
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Journal articles
DOI
DOI : 10.1016/j.celrep.2023.112405
Accès au texte intégral et bibtex
https://hal.science/hal-04238555/file/1-s2.0-S2211124723004163-main.pdf BibTex
titre
Multienzyme deep learning models improve peptide de novo sequencing by mass spectrometry proteomics
auteur
Carlos Gueto-Tettay, Di Tang, Lotta Happonen, Moritz Heusel, Hamed Khakzad, Johan Malmström, Lars Malmström
article
PLoS Computational Biology, 2023, 19 (1), pp.e1010457. ⟨10.1371/journal.pcbi.1010457⟩
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Journal articles
DOI
DOI : 10.1371/journal.pcbi.1010457
Accès au texte intégral et bibtex
https://hal.science/hal-04403345/file/journal.pcbi.1010457.pdf BibTex

2022

Journal articles

titre
Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies
auteur
Therese de Neergaard, Anna Bläckberg, Hanna Ivarsson, Sofia Thomasson, Vibha Kumra Ahnlide, Sounak Chowdhury, Hamed Khakzad, Wael Bahnan, Johan Malmström, Magnus Rasmussen, Pontus Nordenfelt
article
Microbiology Spectrum, 2022, 10 (6), ⟨10.1128/spectrum.02486-22⟩
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Journal articles
DOI
DOI : 10.1128/spectrum.02486-22
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titre
A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function
auteur
Wael Bahnan, Lotta Happonen, Hamed Khakzad, Vibha Kumra Ahnlide, Therese de Neergaard, Sebastian Wrighton, Oscar André, Eleni Bratanis, Di Tang, Thomas Hellmark, Lars Björck, Oonagh Shannon, Lars Malmström, Johan Malmström, Pontus Nordenfelt
article
EMBO Molecular Medicine, 2022, 15 (2), ⟨10.15252/emmm.202216208⟩
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Journal articles
DOI
DOI : 10.15252/emmm.202216208
Accès au texte intégral et bibtex
https://hal.science/hal-04403363/file/main.pdf BibTex
titre
Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2
auteur
Wael Bahnan, Sebastian Wrighton, Martin Sundwall, Anna Bläckberg, Olivia Larsson, Urban Höglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Söderlund Strand, Lotta Happonen, Oscar André, Johannes Kumra Ahnlide, Thomas Hellmark, Vidar Wendel-Hansen, Robert Pa. Wallin, Johan Malmstöm, Lars Malmström, Mats Ohlin, Magnus Rasmussen, Pontus Nordenfelt
article
Frontiers in Immunology, 2022, 12, ⟨10.3389/fimmu.2021.808932⟩
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Journal articles
DOI
DOI : 10.3389/fimmu.2021.808932
Accès au texte intégral et bibtex
https://hal.science/hal-04430479/file/fimmu-12-808932.pdf BibTex

2021

Journal articles

titre
Cheetah-MS: a web server to model protein complexes using tandem cross-linking mass spectrometry data
auteur
Hamed Khakzad, Lotta Happonen, Johan Malmström, Lars Malmström
article
Bioinformatics, 2021, 37 (24), pp.4871-4872. ⟨10.1093/bioinformatics/btab449⟩
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Journal articles
DOI
DOI : 10.1093/bioinformatics/btab449
Accès au texte intégral et bibtex
https://hal.science/hal-04430468/file/btab449.pdf BibTex
titre
Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein Complexes
auteur
Sounak Chowdhury, Hamed Khakzad, Gizem Ertürk Bergdahl, Rolf Lood, Simon Ekstrom, Dirk Linke, Lars Malmström, Lotta Happonen, Johan Malmström
article
mSystems, 2021, 6 (5), pp.e0027121. ⟨10.1128/msystems.00271-21⟩
typdoc
Journal articles
DOI
DOI : 10.1128/msystems.00271-21
Accès au texte intégral et bibtex
https://hal.science/hal-04430483/file/msystems.00271-21.pdf BibTex
titre
Quaternary Structure Modeling Through Chemical Cross-Linking Mass Spectrometry: Extending TX-MS Jupyter Reports
auteur
Hamed Khakzad, Swen Vermeul, Lars Malmström
article
Journal of visualized experiments : JoVE, 2021, 176, ⟨10.3791/60311⟩
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Journal articles
DOI
DOI : 10.3791/60311
Accès au texte intégral et bibtex
https://hal.science/hal-04430492/file/document.pdf BibTex
titre
In vivo Cross-Linking MS of the Complement System MAC Assembled on Live Gram-Positive Bacteria
auteur
Hamed Khakzad, Lotta Happonen, Guy Tran van Nhieu, Johan Malmström, Lars Malmström
article
Frontiers in Genetics, 2021, 11, ⟨10.3389/fgene.2020.612475⟩
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Journal articles
DOI
DOI : 10.3389/fgene.2020.612475
Accès au texte intégral et bibtex
https://hal.science/hal-04429714/file/fgene-11-612475.pdf BibTex
titre
Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology
auteur
Hamed Khakzad, Lotta Happonen, Yasaman Karami, Sounak Chowdhury, Gizem Ertürk Bergdahl, Michael Nilges, Guy Tran van Nhieu, Johan Malmström, Lars Malmström
article
PLoS Computational Biology, 2021, 17 (1), pp.e1008169. ⟨10.1371/journal.pcbi.1008169⟩
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Journal articles
DOI
DOI : 10.1371/journal.pcbi.1008169
Accès au texte intégral et bibtex
https://hal.science/hal-04429695/file/journal.pcbi.1008169.pdf BibTex
titre
The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms
auteur
Mahmudul Hasan, Hamed Khakzad, Lotta Happonen, Anders Sundin, Johan Unge, Uwe Mueller, Johan Malmström, Gunilla Westergren-Thorsson, Lars Malmström, Ulf Ellervik, Anders Malmström, Emil Tykesson
article
Chemical Science, 2021, 12 (5), pp.1869-1885. ⟨10.1039/D0SC05971D⟩
typdoc
Journal articles
DOI
DOI : 10.1039/D0SC05971D
Accès au texte intégral et bibtex
https://hal.science/hal-04429650/file/hkhchemicalsc.pdf BibTex

Preprints, Working Papers, …

titre
ipaA triggers vinculin oligomerization to strengthen cell adhesion during Shigella invasion
auteur
Cesar Valencia-Gallardo, Daniel-Isui Aguilar-Salvador, Hamed Khakzad, Charles Bou-Nader, Christian Malosse, Diogo Borges Lima, Chakir Bello, Benjamin Cocom-Chan, Nicole Quenech’du, Bilal Mazhar, Delphine Javelaud, Jacques Fattaccioli, Alain Mauviel, Marc Fontecave, Atef Asnacios, Julia Chamot-Rooke, Lars Malmström, Guy Tran van Nhieu
article
2021
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Preprints, Working Papers, …
DOI
DOI : 10.1101/773283
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2020

Journal articles

titre
Macromolecular modeling and design in Rosetta: recent methods and frameworks
auteur
Julia Koehler Leman, Brian Weitzner, Steven Lewis, Jared Adolf-Bryfogle, Nawsad Alam, Rebecca Alford, Melanie Aprahamian, David Baker, Kyle Barlow, Patrick Barth, Benjamin Basanta, Brian Bender, Kristin Blacklock, Jaume Bonet, Scott Boyken, Phil Bradley, Chris Bystroff, Patrick Conway, Seth Cooper, Bruno Correia, Brian Coventry, Rhiju Das, René de Jong, Frank Dimaio, Lorna Dsilva, Roland Dunbrack, Alexander Ford, Brandon Frenz, Darwin Fu, Caleb Geniesse, Lukasz Goldschmidt, Ragul Gowthaman, Jeffrey Gray, Dominik Gront, Sharon Guffy, Scott Horowitz, Po-Ssu Huang, Thomas Huber, Tim Jacobs, Jeliazko Jeliazkov, David Johnson, Kalli Kappel, John Karanicolas, Hamed Khakzad, Karen Khar, Sagar Khare, Firas Khatib, Alisa Khramushin, Indigo King, Robert Kleffner, Brian Koepnick, Tanja Kortemme, Georg Kuenze, Brian Kuhlman, Daisuke Kuroda, Jason Labonte, Jason Lai, Gideon Lapidoth, Andrew Leaver-Fay, Steffen Lindert, Thomas Linsky, Nir London, Joseph Lubin, Sergey Lyskov, Jack Maguire, Lars Malmström, Enrique Marcos, Orly Marcu, Nicholas Marze, Jens Meiler, Rocco Moretti, Vikram Khipple Mulligan, Santrupti Nerli, Christoffer Norn, Shane Ó’conchúir, Noah Ollikainen, Sergey Ovchinnikov, Michael Pacella, Xingjie Pan, Hahnbeom Park, Ryan Pavlovicz, Manasi Pethe, Brian Pierce, Kala Bharath Pilla, Barak Raveh, P. Douglas Renfrew, Shourya Burman, Aliza Rubenstein, Marion Sauer, Andreas Scheck, William Schief, Ora Schueler-Furman, Yuval Sedan, Alexander Sevy, Nikolaos Sgourakis, Lei Shi, Justin Siegel, Daniel-Adriano Silva, Shannon Smith, Yifan Song, Amelie Stein, Maria Szegedy, Frank Teets, Summer Thyme, Ray Yu-Ruei Wang, Andrew Watkins, Lior Zimmerman, Richard Bonneau
article
Nature Methods, 2020, 17 (7), pp.665-680. ⟨10.1038/s41592-020-0848-2⟩
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Journal articles
DOI
DOI : 10.1038/s41592-020-0848-2
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titre
Structural proteomics, electron cryo-microscopy and structural modeling approaches in bacteria–human protein interactions
auteur
Sounak Chowdhury, Lotta Happonen, Hamed Khakzad, Lars Malmström, Johan Malmström
article
Medical Microbiology and Immunology, 2020, 209 (3), pp.265-275. ⟨10.1007/s00430-020-00663-5⟩
typdoc
Journal articles
DOI
DOI : 10.1007/s00430-020-00663-5
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2019

Journal articles

titre
A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies
auteur
Lotta Happonen, Simon Hauri, Gabriel Svensson Birkedal, Christofer Karlsson, Therese de Neergaard, Hamed Khakzad, Pontus Nordenfelt, Mats Wikström, Magdalena Wisniewska, Lars Björck, Lars Malmström, Johan Malmström
article
Nature Communications, 2019, 10 (1), pp.2727. ⟨10.1038/s41467-019-10583-5⟩
typdoc
Journal articles
DOI
DOI : 10.1038/s41467-019-10583-5
Accès au texte intégral et bibtex
https://hal.science/hal-04429519/file/s41467-019-10583-5.pdf BibTex
titre
Greedy de novo motif discovery to construct motif repositories for bacterial proteomes
auteur
Hamed Khakzad, Johan Malmström, Lars Malmström
article
BMC Bioinformatics, 2019, 20 (S4), pp.141. ⟨10.1186/s12859-019-2686-8⟩
typdoc
Journal articles
DOI
DOI : 10.1186/s12859-019-2686-8
Accès au texte intégral et bibtex
https://hal.science/hal-04429490/file/s12859-019-2686-8.pdf BibTex
titre
Rapid determination of quaternary protein structures in complex biological samples
auteur
Simon Hauri, Hamed Khakzad, Lotta Happonen, Johan Teleman, Johan Malmström, Lars Malmström
article
Nature Communications, 2019, 10 (1), pp.192. ⟨10.1038/s41467-018-07986-1⟩
typdoc
Journal articles
DOI
DOI : 10.1038/s41467-018-07986-1
Accès au texte intégral et bibtex
https://hal.science/hal-04429464/file/s41467-018-07986-1.pdf BibTex

Poster communications

titre
TX-MS: Targeted chemical cross-linking Mass Spectrometry can determine quaternary protein structures directly in complex samples
auteur
Hamed Khakzad, Lotta Happonen, Johan Malmström, Lars Malmström
article
ISMB/ECCB 2019, Jul 2019, Basel, Switzerland. 2019, ⟨10.7490/f1000research.1117153.1⟩
typdoc
Poster communications
DOI
DOI : 10.7490/f1000research.1117153.1
Accès au texte intégral et bibtex
https://hal.science/hal-04694057/file/f1000research-257236.pdf BibTex

2016

Journal articles

titre
PDB2Graph: A toolbox for identifying critical amino acids map in proteins based on graph theory
auteur
Niloofar Niknam, Hamed Khakzad, Seyed Shahriar Arab, Hossein Naderi-Manesh
article
Computers in Biology and Medicine, 2016, 72, pp.151-159. ⟨10.1016/j.compbiomed.2016.03.012⟩
typdoc
Journal articles
DOI
DOI : 10.1016/j.compbiomed.2016.03.012
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