Welcome!
I am an Associate Professor – HDR (Habilitation to Supervise Research) at the University of Lorraine within the Neurorhythms team, at Loria (Laboratoire Lorrain de Recherche en Informatique et ses Applications) since September 1, 2013. I am currently on leave, working as a Psychiatry Resident and Associate Researcher at Loria, pursuing my research activities.
My research focuses on understanding how the intrinsic dynamics of single neurons influence the behavior of biological neural networks. In particular, I aim to bridge different modeling scales, which is essential for a better understanding of the nervous system. I am especially interested in ionic homeostasis and the role of ion channels in (patho)physiological neural oscillations.
My work has primarily focused on physiologically and anatomically realistic modeling of the hippocampal formation and its interactions with cortical areas, in both healthy and pathological contexts, including sleep, memory, epilepsy, and general anesthesia. More recently, I have been involved in developing a physiologically realistic model of the basal ganglia to better understand rhythmogenesis in Parkinson’s disease. I have also recently begun studying another excitable system, the retina, in the context of neuropsychiatric disorders.
I am currently pursuing research on the modeling of brain and sensory activity to investigate the pathophysiological mechanisms underlying neurological and psychiatric conditions. Computational modeling enables in silico hypothesis testing and allows simulation of the effects of pharmacological or electrical stimulation treatments. One of the medium-term goals of this work is to identify new therapeutic targets.
For more information about my ongoing projects, please visit: https://members.loria.fr/LBuhry/projets/
For the latest news, see: https://members.loria.fr/LBuhry/news/
