I am interested in understanding how intrinsic dynamics of single neurons impact biological neural network behaviors, bridging the gap between modeling scales being necessary to a better understanding of the neuronal/nervous system. I am particularly intrigued by ionic homeostasis and the role of ionic channel in (patho)-physiological neural oscillatory behaviours.
My research activity, up to now, mainly focused on the physiologically and anatomically realistic modeling of the hippocampal formation and its interactions with cortical areas in the contexts of healthy and pathological sleep, memory, epilepsy, and general anesthesia. More recently, I got also involved in the development of a physiologically realistic of the basal ganglia for the understanding of Parkinson’s disease rhythmogenesis and another excitable cell system, the retina, in the context of neuropsychiatric diseases.
I am currently pursuing my research towards the modeling of brain and sensory activity under neurological and psychiatric pathological conditions.
For more information about my ongoing projects, go to .https://members.loria.fr/LBuhry/projets/
For the latest news, see there: https://members.loria.fr/LBuhry/news/