I am interested in understanding how intrinsic dynamics of single neurons impact biological neural network behaviors, bridging the gap between modeling scales being necessary to a better understanding of the neuronal/nervous system. I am particularly intrigued by ionic homeostasis and the role of ionic channel in (patho)-physiological neural oscillatory behaviors.
My research activity, up to now, mainly focused on the physiologically and anatomically realistic modeling of the hippocampal formation and its interactions with cortical areas in the contexts of healthy and pathological sleep, memory, epilepsy, and general anesthesia. More recently, I got also involved in the development of a physiologically realistic model of the basal ganglia for the understanding of Parkinson’s disease rhythmogenesis. Lately, I started to study another excitable cell system, the retina, in the context of neuropsychiatric diseases.
I am currently pursuing my research towards the modeling of brain and sensory activity to investigate pathophysiological mechanisms of neurological and psychiatric conditions. Computational modeling indeed allows in silico hypothesis testing; it also allows to simulate the effects of pharmacological or electrical stimulation treatments. This work aims, among other medium term goals, to identify new therapeutic targets.
For more information about my ongoing projects, go to .https://members.loria.fr/LBuhry/projets/
For the latest news, see there: https://members.loria.fr/LBuhry/news/