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Keywords : computational neuroscience, biophysically realistic mathematical modeling, spiking neurons, Hodgkin-Huxley formalism,memory, epilepsy, general anesthesia, Parkinson disease, hippocampus, basal ganglia

Modeling and Simulation of the Healthy and Epileptic Hippocampus

The hippocampus is involved in several memory processes and exhibits oscillations in a wide range of frequencies correlated with specific functions. These patterns differ in sleep and wakefulness. For instance, theta (5-10Hz) and gamma (30-100Hz) rhythms are typically coupled in spatial navigation and working memory tasks during active wakefulness, whereas delta oscillations (1-4Hz) and Sharp-Wave-Ripple (SWR) complexes (130-200Hz) play an important role in memory consolidation and appear during slow-wave
sleep and quiet wakefulness. In addition, these rhythms are disturbed in pathological conditions such as epilepsy.

In collaboration with:
Motoharu Yoshida, Deutsches Zentrum für Degenerative Erkrankungen, Helmoltz-Gemeinschaft, Magdeburg, Germany : animal neurophysiology
Radu Ranta, Valérie Louis-Dorr, Steven le Cam, Laurent Koessler, Centre de Recherche en Automatique de Nancy (CRAN), Nancy, France: signal processing
Louis Maillard, Louise Tyvaert, Olivier Aaron, Nicolas Carpentier, University Hospital (CHRU)-CRAN, Nancy : neurology, human neurophysiology, epilepsy, sleep


Modeling the Effects of General Anesthesia on Neuronal Activity

Application to the understanding of possible mechanisms underlying memory processes under general anesthesia


Modeling and Simulation of Basal Ganglia

Applications to the understanding of Parkinson’s disease rhythmogenesis

In collaboration with:
Jérôme Beaufreton, Institut des Maladies Neurodégénératives, Bordeaux, France: animal neurophysiology
Dominique Martinez, LORIA
Sylvain Contassot-Vivier, LORIA: High-Performance Computing


Modeling of Electrical Retinal Activity: Applications in Neuropsychiatry

Changes in amplitude and latency of ElectroRetinoGram (ERG) signals are observed under psychiatric conditions and/or in presence of drug consumption.
From a developmental point of view, the retina is an extension of the brain. As such, retinal cells exhibit an electrical activity that can be modeled with the Hodgkin-Hyxley formalism. This project aims at studying the role of ionic channels and ionic homeostasis in pathophysiological neuronal activity

In collaboration with:
Valérie Louis-Dorr, Centre de Recherche en Automatique de Nancy (CRAN), Nancy, France: signal processing
and clinicians from the University Hospital of Nancy


Synchronization Mechanisms in Neuronal Network Models

In collaboration with:
LieJune Shiau, Department of Mathematics, University of Houston Clearlake, Houston, Texas.